© 2015 Elsevier Inc.Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland is the only organ developing predominantly after birth, we utilized it as a powerful system to study (...) adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ -producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation. Plaks et al. (shrink)

Using measures developed by Singhapakdi et al. (1996, Journal of Business ethics 15, 1131–1140) the perceived importance of ethics and social responsibility (PRESOR) is measured among MBA students in the United States, Malaysia and Ukraine revealing a stockholder view and two stakeholder views. Relativism and Idealism are also measured. The scores of MBA students are compared among each other and with those of the U.S. managers who were part of the original study. Managers'' scores tend to be significantly higher on (...) the Stockholder and Stakeholder II views, and much lower on Relativism than the MBA students. The Malaysian MBA students scored higher than did the American MBA students on Relativism, Idealism and the Stockholder view. The Ukrainian MBA students'' scores on the three PRESOR factors are generally similar to those of the American MBAs, while they had the highest scores of any group on the Relativism scale. Overall, the patterns of responses, as much as the significant differences on specific scales, support the notion that culture, however defined, affects both values and ethics. Several directions for future research are identified.''. (shrink)

Au milieu du bouillonnement intellectuel des années vingt en U.R.S.S., Mikhaïl Bakhtine, philosophe et critique littéraire, sʹinterroge sur les rapports entre lʹidéologie, le langage et le psychisme. Refusant la dichotomie saussurienne langue / parole, qui vide la pratique linguistique de sa substance, il affirme la nature sociale du signe et pose les fondements dʹune linguistique de lʹénonciation en tant que manifestation sociale et non individuelle. Au signe figé, réduit à nʹêtre quʹun "signal", il oppose le signe mouvant, changeant, arène où (...) se jouent les conflits sociaux. Publié en 1929 à Leningrad sous le nom de Volochinov, élève de Bakhtine, cet ouvrage paraît pour la première fois sous le nom de son véritable auteur. -- Back cover. (shrink)

Préalables S’il nous paraît important de poursuivre la discussion, appelée de nos vœux, avec les tenants de l’herméneutique « matérielle » / « numérique » (Mayaffre 2006), cette « réplique » (cf. Jullien 2007) aux commentaires que Damon Mayaffre (désormais DM) a pris le temps de nous adresser sera brève, l’ouvrage collectif Corpus numérique, langues et sens. Enjeux épistémologiques et politiques (Debono [dir.], 2014) proposant d’assez larges développements quant aux termes de ce débat. Dans...

One of the movements sharply critical of the Enlightenment was illuminism. Weishaupt, Saint-Martin, Eckertshausen are little more than names today yet in their time they contributed to the birth of a new and rich intellectual world, that of Romanticism. Through the life of a well-to-do citizen of Berne, Kirchberger, we see the fortunes of the illuminists, their hopes, their doubts, their ultimately marginal destiny. The book begins with a careful historical account of the papers of Kirchberger followed by a description (...) of his life. Later on we are introduced into a more speculative world: that of the post-Boehmean speculation on the Divine Sophia. The speculative mysticism of these times was an offspring of heterodox theological speculation and condemned quietistic spirituality. Kirchberger, with his rich and diverse correspondence, is an interesting witness of this movement.--M. J. V. (shrink)

A highly interesting collection of lectures on the central themes of contemporary philosophy and theology in the European tradition. Out of twenty-seven fascinating titles a few especially interesting ones are: Heinrich Ott, "The Structure of the Act of Faith," Karl Kerényi, "The Myth of Faith," Antoine Vergote, "Myth, Belief, and Theological Faith," Henri Bouillard, "To Believe and to Understand," Geo Widengren, "Myth and Faith in the Light of Religious Phenomenology," Giulio Girardi, "Demythisation and Atheism," René Marlé, "Is the Christian Faith (...) a Religion?" Huguette Fugier, "Time and the Sacred in the Religious Vocabulary of the Romans," Renato Lazzarini, "Myth and Faith in Eschatological Perspective." All the lectures and the discussions centered around them are in French.—M. J. V. (shrink)

The present book is an interesting essay on Origen's place in the history of Western thought, or better, about the question whether he was a philosopher at all, and if so, in what sense. Because of his intense speculative drive and his wide learning in Neoplatonic thought Origen has been considered to be the "most philosophical" of the Greek Fathers. Such a view very often entails the attempt at "reorganizing" his thought as systematic philosophical reflection. The author's final thesis is (...) that such an approach is doomed to failure in really understanding the Origenian mind. This "pupil" of Ammonius Saccas was above all a Christian theologian and as such an outsider to philosophy. Philosophy had not been taken for granted by him but it was to be probed into from the depth of Christian experience and its theological self-interpretation. Philosophy itself-which means to his mind pagan philosophy—should be treated within the framework of that vast theological enterprise Origen had been carrying through in his whole life. It is only after the analysis of his philosophy of theology that Origen's contribution to philosophy proper can be evaluated. It is in this sense that the author considers his work as a prolegomenon to "Origenian philosophy."—M. J. V. (shrink)

This book is a rather mediocre and unimaginative summary of the major themes of Avicenna's metaphysics. Chahine makes the attempt to situate him against the background of antique and medieval philosophy, but the ideas themselves are never given a contextual treatment. One does not see what was truly original and significant in Avicenna's philosophy; one is left frustrated by the succession of scholastic lieux communs and only seldom gratified by a beautiful quote. There is a certain amount of information on (...) the ideas of other Islamic thinkers influencing Avicenna or influenced by him, but this cannot compensate for the lack of a really penetrating analysis—M. J. V. (shrink)

This is the first good book on the early Schelling since Metzger's study in 1911. What is more, it is an entirely novel interpretation of this first and most productive decade of Schelling's philosophizing. The central thesis is that Schelling's fundamental intuition had always been that of the concrete and particular character of all reality. Reality is a whole and everything real is a whole: an actual closed totality. Even in this most Fichtean period, Schelling did not really accept the (...) transcendental position, and the philosophy of nature allowed him to expand his vision of the concrete into rich and complex constructions. This is a view which one occasionally encounters in other critical writings on Schelling, but it is usually overpowered by the accumulated Hegelian prejudice concerning Schelling's "dogmatism" and "abstract formalism." It is therefore heartening to see the author, without any polemics, challenging the Hegelians on their own favorite hunting-ground: the arid pastures of the philosophy of identity. Although the author does not fully document her findings, and although the System of Transcendental Idealism is almost totally neglected, the book is undoubtedly an important event. It may even signal the opening of new research into the early Schelling. It is immensely useful--and encouraging--for a number of scholars working on the Ages of the World and on the positive philosophy: it helps them to see the continuity in the six decades of Schelling's philosophizing.--M. J. V. (shrink)

This is the first good book on the early Schelling since Metzger's study in 1911. What is more, it is an entirely novel interpretation of this first and most productive decade of Schelling's philosophizing. The central thesis is that Schelling's fundamental intuition had always been that of the concrete and particular character of all reality. Reality is a whole and everything real is a whole: an actual closed totality. Even in this most Fichtean period, Schelling did not really accept the (...) transcendental position, and the philosophy of nature allowed him to expand his vision of the concrete into rich and complex constructions. This is a view which one occasionally encounters in other critical writings on Schelling, but it is usually overpowered by the accumulated Hegelian prejudice concerning Schelling's "dogmatism" and "abstract formalism." It is therefore heartening to see the author, without any polemics, challenging the Hegelians on their own favorite hunting-ground: the arid pastures of the philosophy of identity. Although the author does not fully document her findings, and although the System of Transcendental Idealism is almost totally neglected, the book is undoubtedly an important event. It may even signal the opening of new research into the early Schelling. It is immensely useful--and encouraging--for a number of scholars working on the Ages of the World and on the positive philosophy: it helps them to see the continuity in the six decades of Schelling's philosophizing.--M. J. V. (shrink)

The emphasis is on extensive textual analysis, concentrated mainly on the Nicomachean Ethics, but making a very generous use of all other writings of the Stagirite. After a long and interesting introduction on Aristotle's method in ethical investigations and on the evolution of his moral philosophy, comes a comprehensive treatment of his theory of happiness: happiness in general, happiness as virtue, happiness and the moral order, the realization of happiness in the practice of wisdom. If the book has a general (...) thesis, it is a kind of apology for Aristotelian ethics as a morality of activity and dynamism which, instead of only aiming at "the formal perfection" of the virtuous man of Plato, opens the way to a theological culmination, to a truly transcendent moral end. Despite an over-abundance of frequently unnecessary quotes from secondary sources, this very scholarly book is a valuable instrument for the systematic reading of the Philosopher from an ethical perspective.—M. J. V. (shrink)

The author is one of the greatest contemporary authorities on Classical Jewish philosophy. He applies his vast scholarship to probe into the inter-relationship between medieval Jewish philosophy and the cabala. The profound and daring speculation of the theosophists of the early cabala did not fail to provoke a violent reaction on the part of Jewish scholasticism, and the two long studies in the present volume try to analyze two cases of such antagonistic relationships. The first of the studies is a (...) comparison of the philosophico-theological treatise of Samuel Judah Ibn Tibbon, "The Reconciliation of Philosophy and the Religious Law," with a treatise on the Spanish cabalist Jacob ben Seset. While in this study we see the confrontation of the spirit of Averroes with the cabalistic inspiration, the second essay is devoted to a treatise from the fourteenth century, written by Joseph ben Abraham Ibn Waquar, in which philosophical and cabalistic elements are intimately interwoven in one and the same work. To the two major studies are added ten highly interesting short treatises on cabalistic notions and texts, making the present books together with the writings of Gershon Scholem the most important monument to cabalistic scholarship available in a Western language.—M. J. V. (shrink)

Karl Barth's younger brother died shortly before the publication of this monumental work, the crowning piece of his long philosophical career. Since Sein und Zeit and L'Etre et le Néant the present book has been the first real "treatise" in what now we might call "the existentialistic tradition." Such a short notice cannot even hope to enumerate the major themes of this huge volume. This is a truly significant work covering most of the themes that attract a passionate concern for (...) the history of Western philosophizing. The continuity with this history is preserved through the determination of existence as knowledge. The question and the quest about appearance is conducted in such a way that neither the existentialist nor the transcendental elements are neglected. Throughout the entire book it is argued that appearance and existence are positively grounded in transcendence.—M. J. V. (shrink)

Malpractice lawsuits serve as a great source of pain, consternation and loss for physicians and patients alike, usually leaving all parties involved in the process with a sense of betrayal. A significant number of physicians will be sued at least once in their career, especially if they practice in some of the more vulnerable specialties. In addition, there is some evidence that the threat of malpractice lawsuits changes the practice style of many physicians, leading to the practice of “defensive medicine” (...) and raises the total cost of health care. Clearly, the prevention of medical malpractice is an issue that deserves considerable attention from physicians and from those who train them.Empirical evidence suggests that medical negligence may play a relatively minor role in malpractice lawsuits. As demonstrated by Localio, et al., one in thirty-five cases of negligence or incompetence actually results in a lawsuit. (shrink)

Malpractice lawsuits serve as a great source of pain, consternation and loss for physicians and patients alike, usually leaving all parties involved in the process with a sense of betrayal. A significant number of physicians will be sued at least once in their career, especially if they practice in some of the more vulnerable specialties. In addition, there is some evidence that the threat of malpractice lawsuits changes the practice style of many physicians, leading to the practice of “defensive medicine” (...) and raises the total cost of health care. Clearly, the prevention of medical malpractice is an issue that deserves considerable attention from physicians and from those who train them.Empirical evidence suggests that medical negligence may play a relatively minor role in malpractice lawsuits. As demonstrated by Localio, et al., one in thirty-five cases of negligence or incompetence actually results in a lawsuit. (shrink)

Afshar et al. claim that their experiment shows a violation of the complementarity inequality. In this work, we study their claim using a modified Mach-Zehnder setup that represents a simpler version of the Afshar experiment. We find that our results are consistent with Afshar et al. experimental findings. However, we show that within standard quantum mechanics the results of the Afshar experiment do not lead to a violation of the complementarity inequality. We show that their claim originates from a particular (...) technique they use to analyze their results. In their analysis, they assume a classical concept, that particles have a definite trajectory before detection, thus, they obtain which-way information by particle detection plus path extrapolation by applying momentum conservation. This analysis technique is standard in experimental particle physics. Important discoveries such as the detection of vector bosons have been made through the application of this technique. We note that particle detection plus path extrapolation is a suitable technique within de Broglie-Bohm theory of quantum mechanics. (shrink)

This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Biomedical Informatics: We Are What We Publish", written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by an editorial. This article contains the combined commentaries invited to independently comment on the Elkin et al. paper. In subsequent issues the discussion can continue through letters to the editor.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Virtue and Grace in the Theology of Thomas Aquinas by Justin M. AndersonThomas V. BergVirtue and Grace in the Theology of Thomas Aquinas by Justin M. Anderson (Cambridge: Cambridge University Press, 2020), xiii + 327 pp.To ignore Aquinas's theological backstory to his account of the virtues—namely, his account of grace in its relation to human action—is to distort his account of the virtues. This is the very valid (...) thesis explored by Justin Anderson in Virtue and Grace in the Theology of Thomas Aquinas. Anderson critiques the tendency among contemporary Anglophone virtue ethicists to quietly bracket his account of grace even as they admire his account the virtues. More pointedly, Anderson holds that Aquinas's account of virtue is inseparable from his account of sin, grace, "and God's presence in human life and action." He endeavors to evidence Aquinas's authentic account of virtue and its "inner reliance on the theological categories of grace, sin, and divine providence" (1).Anderson thus proposes a reading of Aquinas that is diachronic, analytical and systematic, and text-based, and which follows the logic inherent in Aquinas's own reasoning.And he delivers.After a brief overview of Aquinas's understanding of virtue in chapter 1, in chapter 2, Anderson explores the Thomistic distinction that will largely serve as a heuristic for most of the study: the distinction between virtue secundum quid (pagan virtue) and virtue simpliciter, virtue infused in us by God—virtue in the truest sense of the term.In chapter 3, Anderson traces the historical evolution in Aquinas's understanding of grace as this impacts his understanding of the conditions under which a person can possess or embody virtue. He bases this exploration in part on the work of both Henri Bouillard and Bernard Lonergan. First Anderson explores how that evolution came about in the context of the emergence of two powerful categories of thought: the Aristotelian concept of nature in the twelfth century and the category of the supernatural in the thirteenth. According to Bouillard, Aquinas's understanding of grace would [End Page 1421] have been further shaped by two sets of discoveries during his sojourn in Italy in the early 1260s, the first being two anti-Pelagian tracts of St. Augustine, and the second being the Liber de bona fortuna, a Latin compilation, possibly translated by William of Moerbeke, consisting of two chapters on good fortune, one taken from Aristotle's Magna Moralia, and the other from the Eudemian Ethics.Aquinas discovers in Augustine's anti-Pelagian works the contention that the beginning of faith is from God and not from the individual. As with the grace of final perseverance, both initiation and perdurance in faith are gratuitous gifts of God. In his encounter with the Liber (and particularly his consideration therein of the "problem of the first deliberation"), like other medievals, Aquinas "[was] presented Aristotelian investigations regarding the possibility of a divine movement, even unacknowledged by the agent, at the very roots of human action" (98). And, in Thomas's evolved understanding, this divine influence would constitute an inner movement within the human agent apart from those external circumstances ordained by providence.Anderson embraces the thesis that, in this context, and under these influences, Aquinas's understanding of grace underwent a "revolution," that a mature Aquinas—and this is the thesis of Lonergan—moves beyond a consideration of grace merely as habitus (gratia gratum faciens) to a notion of operative grace, of grace as a movement, utilizing "the unique idea of a 'moving grace', a movement of God in, and in some cases with, the human soul" (105).And—Anderson is emphatic—this revolution in thought quickly steers Aquinas clear of what centuries later will be termed semi-Pelagianism, and toward a firmly anti-Pelagian conception of the human capacity for virtue.Chapters 4–9 comprise the second and third parts of the book. It is here that Anderson masterfully and exhaustively engages in the heavy lifting of evincing just how, in fact, Aquinas's account of virtue is inseparable from his theology of grace. On the supposition that Aquinas's mature theology of grace understands the latter to... (shrink)

On June 18, 2023, the U.S. Supreme Court in the matter of Amgen, Inc. et al. v. Sanofi, et al.1 unanimously upheld the 2021 decision of the U.S. Court of Appeals for the Federal Circuit,2 striking down as overbroad Amgen’s patent claim to an entire functional genus of monoclonal antibodies. Amgen’s patent claims were not limited to antibody structure or antibody amino acid sequences. This is significant because Amgen’s patent claims did have amino acid sequences, but they were directed to (...) the epitope. (shrink)